🌿 4-Hydroxyisoleucine: The Key Amino Acid Supporting Blood Sugar & Muscle Health
🌿 4-Hydroxyisoleucine: The Key Amino Acid Supporting Blood Sugar & Muscle Health
4-Hydroxyisoleucine (4-HIL) is a naturally occurring amino acid found in fenugreek seeds (Trigonella foenum-graecum).
It has attracted growing scientific and industry attention for its ability to regulate blood sugar and improve muscle metabolism, making it a valuable bioactive for metabolic health, fitness, and dietary supplements.
💉 What Is 4-Hydroxyisoleucine?
4-Hydroxyisoleucine is a non-proteinogenic amino acid, meaning it does not directly build proteins but acts as a powerful metabolic regulator.
Naturally present in fenugreek seeds (about 0.1–0.5%), this compound helps promote balanced glucose metabolism and improve insulin efficiency.
⚙️ How It Works – Mechanism of Action
Scientific studies suggest that 4-Hydroxyisoleucine works through two main biological pathways:
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Stimulating Insulin Secretion – It activates pancreatic β-cells in a glucose-dependent manner, helping the body release insulin only when blood sugar levels are high.
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Enhancing Muscle Glucose Uptake – It increases cellular glucose absorption and glycogen storage, supporting energy metabolism and muscle performance.
Together, these actions improve insulin sensitivity and reduce the risk of metabolic imbalance.
🩸 Key Health Benefits
🌿 Supports healthy blood sugar levels
💪 Improves muscle recovery and endurance
⚖️ Aids in weight management and appetite control
❤️ Promotes cardiovascular and metabolic wellness
🔬 Acts as a natural insulin sensitizer
🧩 Applications in Nutritional Formulas
4-Hydroxyisoleucine is widely used in:
Blood sugar support and glucose balance formulas
Sports nutrition and muscle recovery products
Weight management and appetite control supplements
Fenugreek-based nutraceuticals and herbal blends
🧪 Product Information – SGBio 4-Hydroxyisoleucine Extract
At SGBio, our 4-Hydroxyisoleucine extract is produced under GMP and ISO-certified facilities to ensure consistent quality and purity.
| Property | Details |
|---|---|
| Botanical Source | Trigonella foenum-graecum (Fenugreek) |
| Active Compound | ≥ 40% 4-Hydroxyisoleucine (HPLC) |
| Appearance | Light brown to yellow powder |
| Solubility | Water-soluble |
| Shelf Life | 24 months |
| Packaging | 1kg foil bag / 25kg drum |
| Certificates | CoA, MSDS, Third-party tested |
🌱 Why Choose SGBio?
✅ High-purity fenugreek extract with standardized 4-HIL content
🌿 Non-GMO, vegan-friendly, and solvent-free production
🧾 Comprehensive documentation: CoA, MSDS, third-party test reports
🚚 Fast and reliable global delivery from New Zealand
💬 Frequently Asked Questions
Q: Is 4-Hydroxyisoleucine safe for daily use?
A: Yes. It’s a naturally derived amino acid with excellent human safety data and is well-tolerated even at higher doses.
Q: Can I combine it with other herbal actives?
A: Absolutely! It pairs well with Gymnema sylvestre, Berberine, and Banaba extract for enhanced glucose regulation and metabolic balance.
Q: What is the typical dosage range?
A: Commonly used dosages in dietary supplements range from 50–200 mg per day, depending on formulation.
